血中β-アミロイド値が将来の認知機能障害・認知症のバイオマーカーとなる？ | 内科開業医のお勉強日記
ベースライン認知症無しの老人の前向きコホート研究で、Yaffeらは、1年次の低血中β-アミロイド42/40が9年後の認知症減少と関連することを見いだした。 Bretelerは、これが認知機能減弱と、アルツハイマー病のバイオマーカーとして有望か議論 Association of Plasma β-Amyloid Level and Cognitive Reserve With Subsequent Cognitive Decline JAMA. 2011;305(3):261-266. 髄液では以下の報告などがあるようだ Prediction of Alzheimer’s Disease Using the CSF Aβ42/Aβ40 Ratio in Patients with Mild Cognitive Impairment Dementia and geriatric cogniti
Microglia and inflammation in Alzheimer's disease - PubMed
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Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics
Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics Bradford C Dickerson1,2,3,4, David A Wolk5,6,7, the Alzheimer's Disease Neuroimaging Initiative1Frontotemporal Dementia Unit, Boston, Massachusetts, USA2Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston
ASL Perfusion MRI Predicts Cognitive Decline and Conversion From MCI to Dementia
As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Alzheimer Dis Assoc Disord. Author manuscript; available in PMC 2010 May 6.
Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI
Abstract Objectives: To test if arterial spin labeling (ASL) MRI could detect a pattern of hypoperfusion in frontotemporal dementia (FTD) vs cognitively normal (CN) control subjects; to determine the regional difference of perfusion between FTD and Alzheimer disease (AD); and to determine whether hypoperfusion in FTD correlates with cognitive impairment. Methods: We included 21 patients with FTD,
Arch Neurol -- Abstract: Longitudinal Changes in White Matter Disease and Cognition in the First Year of the Alzheimer Disease Neuroimaging Initiative, November 2010, Carmichael et al. 67 (11): 1370
Example white matter hyperintensity (WMH) detection results for 3 individuals whose WMH distributions are representative of the broader sample. Detected WMHs are overlaid in white on slices of T1-weighted images. Each row shows a set of 3 slices for a given individual. Each column shows detection at an analogous slice across all 3 individuals. The 3 individuals differ in their WMH distribution: th
Homocysteine and holotranscobalamin and the risk of Alzheimer disease: A longitudinal study -- Hooshmand et al. 75 (16): 1408 -- Neurology
A longitudinal study B. Hooshmand, MD, MSc, A. Solomon, MD, PhD, I. Kåreholt, PhD, J. Leiviskä, MSc, M. Rusanen, MD, S. Ahtiluoto, MD, B. Winblad, MD, PhD, T. Laatikainen, MD, PhD, H. Soininen, MD, PhD and M. Kivipelto, MD, PhD From the Aging Research Center (B.H., A.S., I.K., B.W., M.K.) and KI Alzheimer's Disease Research Center (KI-ADRC) (B.H., B.W., M.K.), Department of Neurobiology, Care Scie
Psychiatry Research: Neuroimaging | Journal | ScienceDirect.com by Elsevier
Psychiatry Research: Neuroimaging, a companion title to Psychiatry Research, focuses on publications relating to imaging techniques. We publish manuscripts on magnetic resonance imaging, positron emission tomography, multichannel electrophysiology, near-infrared spectroscopy, computed tomography, magnetoencephalography, non-invasive brain stimulation, autoradiography, post-mortem regional analyses
Midlife Smoking, Apolipoprotein E and Risk of Dementia and Alzheimer’s Disease: A Population-Based Cardiovascular Risk Factors, Aging and Dementia Study
Midlife Smoking, Apolipoprotein E and Risk of Dementia and Alzheimer’s Disease: A Population-Based Cardiovascular Risk Factors, Aging and Dementia Study Rusanen M.a, b · Rovio S.f · Ngandu T.a, c · Nissinen A.c · Tuomilehto J.c–e · Soininen H.a, b · Kivipelto M.a, f Author affiliations aDepartment of Neurology, University of Eastern Finland, and bDepartment of Neurology, Kuopio University Hospital
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Diabetes, microvascular pathology and Alzheimer disease - Nature Reviews Neurology
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Differential deposition of amyloid beta peptides in cerebral amyloid angiopathy associated with Alzheimer's disease and vascular dementia - PubMed
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IngentaConnect Comparison between Alzheimer's disease and vascular dementia: Imp...
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https://www.ahajournals.org/doi/full/10.1161/01.str.0000127420.10990.76
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Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer’s disease, and dementia with Lewy bodies
Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis
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