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It should perhaps be stressed that the viral concept does not preclude a major role for Aβ and P-tau in the etiology of AD, even though their effects are still little understood; instead it suggests a cause of their accumulation—namely, HSV1 infection. Further, in HSV1- infected cells in culture, treatment with various types of antiviral have been found to decrease the level of Aβ and particularly
IntroductionThroughout the animal kingdom, contests over limited resources (e.g., mate, territory, and food) are widespread but may entail high costs in terms of time, energy and risk of injury (Huntingfold and Turner, 1987). Behavior in iterated animal contests may be influenced by prior experiences (Hsu et al., 2006), potentially reducing costs or incidence of fighting in repeated encounters. Wi
With just a few lines of code, the user can correct motion artifacts in the data, and then segment the resulting ImagingDataset object to identify ROIs: dataset = sima.motion.hmm( [[channel_A, channel_B]], ’/save/path.sima’) dataset.segment() If the data lack motion artifacts (e.g., in the case of fluorescence imaging in ex vivo brain slices), the motion correction step can be replaced with direct
INTRODUCTIONThe ability to actively select social partners on the basis of relevant characteristics critically shapes the acquisition of knowledge; selecting social partners constrains the kinds of people to which an individual is exposed which can, in turn, guide subsequent attitudes and behaviors. A variety of research suggests that adults systematically select social partners on the basis of se
IntroductionThe ability to choose one's own action is one of the most salient features of our daily experience. In the literature, the status and nature of free will is still debated (Haggard, 2011; Smith, 2011). Causal determinism is the fundamental assumption in the physical sciences, and provides an implicit framework for chemical and biological sciences. The libertarian position on free will (
Credit left to right: Andrew Laurita, Elif Karakoc, Marianne Keller, Abiola Sylvestre Chaffra, Michaela Součková. Playing lemurs and a ‘koala brain atlas’: Here are Frontiers’ photo highlights of the monthAt Frontiers, we bring some of the world’s best research to a global audience. But with tens of thousands of articles published each year, it’s impossible to see all that research in the same way
FIGURE 1. (A) Electrode locations in the motor areas of the lateral aspect of the frontal lobe of the left (contralesional) hemisphere. Electrodes were placed in primary motor cortex (blue dots) and in dorsal premotor cortex (red dots). (B,C) Somatotopic map shows movements evoked from each site in frontal lobe before (B) and after (C) spinal cord injury. The pre-lesion maps were established by IC
The human brain has often been viewed as outstanding among mammalian brains: the most cognitively able, the largest-than-expected from body size, endowed with an overdeveloped cerebral cortex that represents over 80% of brain mass, and purportedly containing 100 billion neurons and 10× more glial cells. Such uniqueness was seemingly necessary to justify the superior cognitive abilities of humans o
Who we are Mission and valuesHistoryLeadershipAwardsImpact and progress Frontiers' impactOur annual reportsThought leadershipPublishing model How we publishOpen accessPeer reviewResearch integrityResearch TopicsFAIR² Data ManagementFee policyServices SocietiesNational consortiaInstitutional partnershipsCollaboratorsMore from Frontiers Frontiers ForumFrontiers Planet PrizePress officeSustainability
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