BioRuby/ChemRuby http://www.tmd.ac.jp/artsci/biol/textbook/celltop.htm 0 70 140 210 280 350 1995 96 97 98 99 2000 01 02 03 04 05 2000 / 1 / 27 • • • RefSeq PDB PubMed PubChem GenPept EMBL UniProt GenBank DNA( , ) DB GENES ENZYME PATHWAY COM POUND UCSC Ensembl KEGG DAS Bio::DAS (REST CGI) Bio::Flat(BDB) Bio::Fetch(HTTP) Bio::SQL(RDB) Bio::KEGG::API (SOAP/WSDL) Bio::GenBank, Bio::EMBL etc. E-Utils (