EURL ECVAM is an integral part of the Joint Research Centre (JRC), the science and knowledge service of the European Commission. It is located in the JRC site in Ispra, Italy. For over 30 years, the JRC has been working on the Three Rs – the Replacement, Reduction and Refinement of animal experiments. The mandate of EURL ECVAM is set out in the EU legislation on the protection of animals used for