TK-Tony
Biography: Prof. Tony Kouzarides PhD, FMedSci, FRS Tony Kouzarides is Professor of Cancer Biology at the University of Cambridge, Deputy Director of the Gurdon Institute and Director of the Milner Therapeutics Institute. Tony did his PhD at the University of Cambridge and postdoctoral work at MRC Laboratory of Molecular Biology on the cancer inducing potential of human cytomegalovirus. He then wen
Genetic origins of the Minoans and Mycenaeans
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1000 Genomes | A Deep Catalog of Human Genetic Variation
The International Genome Sample Resource The 1000 Genomes Project created a catalogue of common human genetic variation, using openly consented samples from people who declared themselves to be healthy. The reference data resources generated by the project remain heavily used by the biomedical science community. The International Genome Sample Resource (IGSR) maintains and shares the human genetic
“Heroes of CRISPR” Disputed
In a perspective piece published in Cell this week (January 14), Eric Lander, president and director of the Broad Institute of MIT and Harvard, outlined the history of achievements behind the precision gene-editing technique known as CRISPR. The problem is, the Broad is a copatentee embroiled in an intellectual property battle being investigated by the US Patent and Trademark Office (USPTO). And L
Addgene: CRISPR Guide
CRISPR Overview Class 2 Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) systems, which form an adaptive immune system in bacteria, have been modified for genome engineering. Prior to CRISPR, genome engineering approaches like zinc finger nucleases (ZFNs) or transcription-activator-like effector nucleases (TALENs) required scientists to design and generate a new nuclease pair for
Zhuang Research Lab
Understanding the mechanisms of cellular function and their dysfunction in disease requires a detailed picture of the molecular interactions in cells. In particular, we need imaging tools with single-molecule sensitivity, molecular-scale resolution, and dynamic imaging capability to allow direct visualization of molecular interactions in cells, as well as tools that can simultaneously image large
Systems, Synthetic, and Quantitative Biology | The Harvard Kenneth C. Griffin Graduate School of Arts and Sciences
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IUPAC ambiguity codes. Nucleotide ambiguity code. Nomenclature for Incompletely Specified Bases in Nucleic Acid Sequences.
Code example: Restriction enzyme: AarI Recognition site: CACCTGCNNNN'NNNN_ Cleavage of DNA (/): 5'- C A C C T G C N N N N/N N N N -3' 3'- G T G G A C G N N N N N N N N/-5' The letter codes and compliment translations are those proposed by Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-UIBMB) Note: DNA Sequence Assembler can automatically detect SNP and
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So long to the silos - Nature Biotechnology
The Heroes of CRISPR
People | Columbia University Department of Systems Biology
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Eric S. Lander
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