A nested case-control study Mahyar Etminan, PharmD, Ali Samii, MD and James M. Brophy, MD, PhD, FRCPC From the Center for Clinical Epidemiology and Evaluation (M.E.), Vancouver Coastal Health Research Institute, Canada; Department of Medicine (M.E.), University of British Columbia, Vancouver, Canada; Department of Neurology (A.S.), University of Washington, Seattle, WA; and Department of Medicine

A randomized controlled trial Karl B. Alstadhaug, MD, PhD, Francis Odeh, MD, PhD, Rolf Salvesen, MD, PhD and Svein I. Bekkelund, MD, PhD From the Department of Neurology (K.B.A., F.O., R.S.), Nordlandssykehuset Bodø, Bodø; Department of Neurology (S.I.B.), University Hospital of North Norway, Tromsø; and Institute of Clinical Medicine (K.B.A., R.S., S.I.B.), University of Tromsø, Tromsø, Norway. A

A.H. Ford, MD, L. Flicker, MD, H. Alfonso, PhD, J. Thomas, RN, R. Clarnette, MD, R. Martins, PhD and O.P. Almeida, MD From the Centre for Medical Research & School of Psychiatry and Clinical Neurosciences (A.H.F., H.A., R.M., O.P.A.) and the Centre for Medical Research & School of Medicine and Pharmacology (L.F., J.T.), WA Centre for Health & Ageing, University of Western Australia, Perth, WA; and

A longitudinal study B. Hooshmand, MD, MSc, A. Solomon, MD, PhD, I. Kåreholt, PhD, J. Leiviskä, MSc, M. Rusanen, MD, S. Ahtiluoto, MD, B. Winblad, MD, PhD, T. Laatikainen, MD, PhD, H. Soininen, MD, PhD and M. Kivipelto, MD, PhD From the Aging Research Center (B.H., A.S., I.K., B.W., M.K.) and KI Alzheimer's Disease Research Center (KI-ADRC) (B.H., B.W., M.K.), Department of Neurobiology, Care Scie

The Cardiovascular Health Study K.I. Erickson, PhD*, C.A. Raji, PhD*, O.L. Lopez, MD, J.T. Becker, PhD, C. Rosano, MD, MPH, A.B. Newman, MD, MPH, H.M. Gach, PhD, P.M. Thompson, PhD, A.J. Ho, BS and L.H. Kuller, MD, DrPh From the Departments of Psychology (K.I.E., J.T.B.), Pathology (C.A.R.), Radiology (C.A.R., H.M.G.), Neurology (O.L.L., J.T.B.), and Epidemiology (C.R., A.B.N., L.H.K.), and Wester

IFNβ-1b may severely exacerbate Japanese optic-spinal MS in neuromyelitis optica spectrum J. Shimizu, MD, PhD, Y. Hatanaka, MD, PhD, M. Hasegawa, MD, A. Iwata, MD, PhD, I. Sugimoto, MD, H. Date, PhD, J. Goto, MD, PhD, T. Shimizu, MD, PhD, M. Takatsu, MD, PhD, Y. Sakurai, MD, PhD, H. Nakase, MD, PhD, Y. Uesaka, MD, PhD, H. Hashida, MD, PhD, K. Hashimoto, MD, PhD, T. Komiya, MD, PhD and S. Tsuji, MD

J.F. Sumowski, PhD, G.R. Wylie, DPhil, A. Gonnella, EdM, N. Chiaravalloti, PhD and J. DeLuca, PhD From the Kessler Foundation Research Center (J.F.S., G.R.W., N.C., J.D.), West Orange; Departments of Physical Medicine and Rehabilitation (J.F.S., G.R.W., N.C., J.D.) and Neurology and Neurosciences (J.D.), UMDNJ–New Jersey Medical School, Newark, NJ; and Department of Health and Behavior Studies (J.

G.A. Kerchner, MD, PhD, C.P. Hess, MD, PhD, K.E. Hammond-Rosenbluth, PhD, D. Xu, PhD, G.D. Rabinovici, MD, D.A.C. Kelley, PhD, D.B. Vigneron, PhD, S.J. Nelson, PhD and B.L. Miller, MD From the Stanford Center for Memory Disorders (G.A.K.), Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford; Memory and Aging Center, Department of Neurology (G.A.K., G

M.I. Aguilar, MD, E.S. O'Meara, PhD, S. Seliger, MD, MS, W.T. Longstreth, Jr., MD, MPH, R.G. Hart, MD, P.E. Pergola, MD, M.G. Shlipak, MD, MPH, R. Katz, DPhil, M.J. Sarnak, MD, MS and D.E. Rifkin, MD, MS From the Division of Neurology (M.I.A.), Mayo Clinic Arizona, Phoenix; Group Health Research Institute (E.S.O.), Seattle, WA; Division of Nephrology (S.S.), University of Maryland School of Medici

A systematic review B.B. Thompson, MD, Y. Béjot, MD, V. Caso, MD, J. Castillo, MD, PhD, H. Christensen, MD, PhD, DMSci, M.L. Flaherty, MD, C. Foerch, MD, K. Ghandehari, MD, FSLP, M. Giroud, MD, S.M. Greenberg, MD, PhD, H. Hallevi, MD, J.C. Hemphill, III, MD, MAS, P. Heuschmann, MD, S. Juvela, MD, PhD, K. Kimura, MD, P.K. Myint, MD, Y. Nagakane, MD, H. Naritomi, MD, S. Passero, MD, M.R. Rodríguez-

A population-based neuropathologic study S. Ahtiluoto, MD, T. Polvikoski, MD, PhD, M. Peltonen, PhD, A. Solomon, MD, PhD, J. Tuomilehto, MD, MA, PhD, B. Winblad, MD, PhD, R. Sulkava, MD, PhD and M. Kivipelto, MD, PhD From the Department of Chronic Disease Prevention (S.A., M.P.), National Institute for Health and Welfare, Helsinki, Finland; Institute for Ageing and Health (T.P.), Newcastle Univers

A 3-year follow-up S.G.C. van Elderen, MD, A. de Roos, MD, A.J.M. de Craen, PhD, R.G.J. Westendorp, MD, G.J. Blauw, MD, J.W. Jukema, MD, E.L.E.M. Bollen, MD, H.A.M. Middelkoop, MD, M.A. van Buchem, MD and J. van der Grond, PhD From the Departments of Radiology (S.G.C.v.E., A.d.R., M.A.v.B., J.v.d.G.), Gerontology and Geriatrics (A.J.M.d.C., R.G.J.W., G.J.B.), Cardiology (J.W.J.), and Neurology (E.

V.S. Kosti, MD, F. Agosta, MD, I. Petrovi, MD, S. Galantucci, MD, V. pica, MD, M. Jemenica-Lukic, MD and M. Filippi, MD From the Department of Neurology (V.S.K., I.P., V.., M.J.-L.), School of Medicine, University of Belgrade, Belgrade, Serbia; and Neuroimaging Research Unit (F.A., S.G., M.F.), Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospi

The Hisayama Study T. Matsuzaki, MD, K. Sasaki, MD, PhD, Y. Tanizaki, MD, PhD, J. Hata, MD, PhD, K. Fujimi, MD, PhD, Y. Matsui, MD, PhD, A. Sekita, MD, S.O. Suzuki, MD, PhD, S. Kanba, MD, PhD, Y. Kiyohara, MD, PhD and T. Iwaki, MD, PhD From the Departments of Neuropathology (T.M., K.S., K.F., S.O.S., T.I.), Psychiatry (T.M., K.S., K.F., Y.M., A.S., S.K.), and Environmental Medicine (Y.T., J.H., Y.

SAMURAI rt-PA Registry T. Nezu, MD, M. Koga, MD, K. Kimura, MD, Y. Shiokawa, MD, J. Nakagawara, MD, E. Furui, MD, H. Yamagami, MD, Y. Okada, MD, Y. Hasegawa, MD, K. Kario, MD, S. Okuda, MD, K. Nishiyama, MD, M. Naganuma, MD, K. Minematsu, MD and K. Toyoda, MD From the Department of Cerebrovascular Medicine (T.N., M.K., M.N., K.M., K.T.), National Cerebral and Cardiovascular Center, Suita; Departme

D.O. Claassen, MD, K.A. Josephs, MD, MST, J.E. Ahlskog, MD, PhD, M.H. Silber, MB, ChB, M. Tippmann-Peikert, MD and B.F. Boeve, MD From the Department of Neurology (D.O.C., K.A.J., J.E.A., M.H.S., M.T.-P., B.F.B.) and Center for Sleep Medicine (M.H.S., M.T.-P., B.F.B.), Mayo Clinic College of Medicine, Rochester, MN. Address correspondence and reprint requests to Dr. Bradley F. Boeve, Department of

S.M. Landau, PhD, D. Harvey, PhD, C.M. Madison, MS, E.M. Reiman, MD, N.L. Foster, MD, P.S. Aisen, MD, R.C. Petersen, MD, PhD, L.M. Shaw, PhD, J.Q. Trojanowski, MD, PhD, C.R. Jack, Jr., MD, M.W. Weiner, MD, W.J. Jagust, MD On behalf of the Alzheimer's Disease Neuroimaging Initiative From the Helen Wills Neuroscience Institute (S.M.L., C.M.M., W.J.J.), University of California, Berkeley; Department

Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology P.D. Schellinger, MD, PhD, R.N. Bryan, MD, PhD, L.R. Caplan, MD, J.A. Detre, MD, R.R. Edelman, MD, C. Jaigobin, MD, C.S. Kidwell, MD, J.P. Mohr, MD, M. Sloan, MD, MS, A.G. Sorensen, MD and S. Warach, MD, PhD From the National Institutes of Neurological Disorders and Stroke (P.D.S., S.W.), NIH, Be

The LADIS Study A. Verdelho, MD, S. Madureira, PsyD, C. Moleiro, PsyD, PhD, J.M. Ferro, MD, PhD, C.O. Santos, PsyD, T. Erkinjuntti, MD, PhD, L. Pantoni, MD, PhD, F. Fazekas, MD, M. Visser, MD, PhD, G. Waldemar, MD, DMSc, A. Wallin, MD, PhD, M. Hennerici, MD, D. Inzitari, MD On behalf of the LADIS Study From the Neurosciences Department (A.V., S.M., J.M.F., C.O.S.), Lisbon University, Santa Maria H

P. Vemuri, PhD, H.J. Wiste, BA, S.D. Weigand, MS, D.S. Knopman, MD, J.Q. Trojanowski, MD, PhD, L.M. Shaw, PhD, M.A. Bernstein, PhD, P.S. Aisen, MD, M. Weiner, MD, R.C Petersen, MD, PhD, C.R Jack, Jr., MD On behalf of the Alzheimer's Disease Neuroimaging Initiative From the Aging and Dementia Imaging Research Laboratory, Department of Radiology (P.V., M.A.B., C.R.J.), Health Sciences Research (H.J.