Brain lesions are most often reversible in acute thrombotic thrombocytopenic purpura Tamika M. Burrus, MD, Eelco F.M. Wijdicks, MD, PhD and Alejandro A. Rabinstein, MD From the Department of Neurology, Mayo Clinic, Rochester, MN. Address correspondence and reprint requests to Dr. Alejandro A. Rabinstein, 200 First St. SW, Mayo W8, Rochester, MN 55905 rabinstein.alejandro{at}mayo.edu. Background: