“Collagenase was significantly better than placebo. There was no evidence that collagenase was clinically better or worse than surgical treatments. LF was the most cost-effective choice to treat moderate to severe contractures, whereas collagenase was not. However, the results of the cost-utility

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Collagenase clostridium histolyticum for the treatment of Dupuytren's contracture: systematic review and economic evaluation - PubMed

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