Yes – one-way car hire in the USA is possible. If you want to drive coast to coast from Chicago to LA, or between any other cities, just choose a different drop-off location. Be aware that many car hire companies charge a One Way Fee, also known as a drop charge, for this type of rental. When you search for a one-way rental in the USA on Rentalcars.com, we tell you (before you book) if a car hire