Ashkenazi Jews (AJ), identified as Jewish individuals of Central- and Eastern European ancestry, form the largest genetic isolate in the United States. AJ demonstrate distinctive genetic characteristics1,2, including high prevalence of autosomal recessive diseases and relatively high frequency of alleles that confer a strong risk of common diseases, such as Parkinson’s disease3 and breast and ovar
![Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins - Nature Communications](https://cdn-ak-scissors.b.st-hatena.com/image/square/31fcf741191596ff4357926cae50c2b9b8117459/height=288;version=1;width=512/https%3A%2F%2Fmedia.springernature.com%2Fm685%2Fspringer-static%2Fimage%2Fart%253A10.1038%252Fncomms5835%2FMediaObjects%2F41467_2014_Article_BFncomms5835_Fig1_HTML.jpg)