Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha, Sayan Mukherjee, Benjamin L. Ebert, Michael A. Gillette, Amanda Paulovich, Scott L. Pomeroy, Todd R. Golub, Eric S. Lander, and Jill P. Mesirov aBroad Institute of Massachusetts Institute of Technology and Harvard, 320 Charles Street, Cambrid