Following the steps below should install nghttp2 with all of its useful apps for testing into /usr/local/http2-15 of your OS X machine. -- openssl % wget --no-check-certificate https://www.openssl.org/source/openssl-1.0.2-beta3.tar.gz % tar xzf openssl-1.0.2-beta3.tar.gz % cd openssl-1.0.2-beta3 % KERNEL_BITS=64 ./config shared enable-ec_nistp_64_gcc_128 --prefix=/usr/local/http2-15 % make % make