Association of Alcohol Consumption With Brain Volume in the Framingham StudyMean total cranial brain volume, including confidence intervals illustrated as error bars, adjusted for age, sex, body mass index (calculated as weight in kilograms divided by height in meters squared), and Framingham Stroke Risk Profile (slope = −0.25; P < .01; R2 = 0.96). TCV indicates total cranial volume; low, 1 to 7 drinks per week; moderate, 8 to 14 drinks per week; and high, more than 14 dr
