Sagittal and axial views of positron emission tomographic (PET) scans of representative patients. The vertical bars indicate the range of semiautomated quantitative analysis of the ratio of cortical to cerebellar signal (SUVr) scores. The maximum color (red) corresponds to an SUVr of approximately 2.2. The 4G8 immunohistochemistry shows precuneus gray matter with aggregated β-amyloid (red) using a

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Forty-seven participants' randomization stratum was changed after randomization, based on a review of the participants' past medical history: 39 from paroxysmal to persistent and 8 from persistent to paroxysmal atrial fibrillation. Efficacy analyses were based on the revised classification and are reflected in the modified intention-to-treat efficacy population. ECG indicates electrocardiography.

A regional white matter atlas was created on our standard template and used to parcellate right and left periventricular (PV), subcortical (SC), and lobar white matter hyperintensity volumes in subject space to compensate for intersubject variation. Four representative slices can be found proceeding from the inferior (top left) to superior (bottom right) direction. 1 Indicates SC frontal; 2, PV fr

Example white matter hyperintensity (WMH) detection results for 3 individuals whose WMH distributions are representative of the broader sample. Detected WMHs are overlaid in white on slices of T1-weighted images. Each row shows a set of 3 slices for a given individual. Each column shows detection at an analogous slice across all 3 individuals. The 3 individuals differ in their WMH distribution: th

Complete baseline data were available for 67 888 patients at time of baseline publication. Complete 1-year follow-up data were available for 64 977 patients (lost to follow-up were 3248 patients who did not attend 1-year visit and 11 who withdrew consent). At the 3-year follow-up, 48 050 patients were eligible. Complete 3-year follow-up data were available for 36 608 patients (2301 died before the

Variable importance plot of protein biomarkers measured by the random forest built from the training set. ACE indicates angiotension converting enzyme; creatine kinase MB, creatine kinase muscle-brain; IL, interleukin; MCP1, monocyte chemoattractant protein 1; MIF, macrophage migration inhibitory factor; MIP1α, macrophage inflammatory protein 1-α; PARC, pulmonary and activation-regulated chemokine

Receiver operating characteristic curve analysis for cerebrospinal fluid–derived β-amyloid protein 1-42 (CSF Aβ1-42)–based identification of Alzheimer disease (AD). Sensitivity (“true-positive rate”) was assessed in the AD group, and specificity (“false-positive rate”) was assessed in the normal group. AUC indicates area under the curve. Numbers with arrows indicate optimal decision boundaries (1)

Figure. Cumulative Risk of All-Cause Mortality and Recurrent Acute Coronary Syndrome (ACS) Among Patients Taking Clopidogrel After Hospital Discharge for ACS and Prescribed a Proton Pump Inhibitor (PPI) at Hospital Discharge or During Follow-up (n = 5244) The number at risk indicates the number of individuals at risk for each period during the 90-day interval with medication use as the time-varyin