Sagittal and axial views of positron emission tomographic (PET) scans of representative patients. The vertical bars indicate the range of semiautomated quantitative analysis of the ratio of cortical to cerebellar signal (SUVr) scores. The maximum color (red) corresponds to an SUVr of approximately 2.2. The 4G8 immunohistochemistry shows precuneus gray matter with aggregated β-amyloid (red) using a

Figure. Multivariate Mixed-Effects Model for Adjusted Mean 3MS Score by Years of Follow-up, Education/Literacy Level, and β-Amyloid 42/40 High/Low Tertiles 3MS indicates Modified Mini-Mental State Examination. Error bars indicate 95% confidence intervals (CIs). A, For education level, models are adjusted for age, race, diabetes, smoking, and apolipoprotein E (APOE) e4 status; the interaction term

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Brain regions in which a lower cerebral glucose metabolic rate was associated with greater insulin resistance as indexed by the homeostasis model assessment of insulin resistance. Regions in which the strongest negative associations were observed are represented in yellow. The vertical bar shows image color vs Z score scale. Image views are labeled as follows: R, right; L, left; Lat, lateral; Sup,

Forty-seven participants' randomization stratum was changed after randomization, based on a review of the participants' past medical history: 39 from paroxysmal to persistent and 8 from persistent to paroxysmal atrial fibrillation. Efficacy analyses were based on the revised classification and are reflected in the modified intention-to-treat efficacy population. ECG indicates electrocardiography.

Example white matter hyperintensity (WMH) detection results for 3 individuals whose WMH distributions are representative of the broader sample. Detected WMHs are overlaid in white on slices of T1-weighted images. Each row shows a set of 3 slices for a given individual. Each column shows detection at an analogous slice across all 3 individuals. The 3 individuals differ in their WMH distribution: th

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Complete baseline data were available for 67 888 patients at time of baseline publication. Complete 1-year follow-up data were available for 64 977 patients (lost to follow-up were 3248 patients who did not attend 1-year visit and 11 who withdrew consent). At the 3-year follow-up, 48 050 patients were eligible. Complete 3-year follow-up data were available for 36 608 patients (2301 died before the

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Figure. Cumulative Risk of All-Cause Mortality and Recurrent Acute Coronary Syndrome (ACS) Among Patients Taking Clopidogrel After Hospital Discharge for ACS and Prescribed a Proton Pump Inhibitor (PPI) at Hospital Discharge or During Follow-up (n = 5244) The number at risk indicates the number of individuals at risk for each period during the 90-day interval with medication use as the time-varyin