Use of Florbetapir-PET for Imaging β-Amyloid Pathology
Sagittal and axial views of positron emission tomographic (PET) scans of representative patients. The vertical bars indicate the range of semiautomated quantitative analysis of the ratio of cortical to cerebellar signal (SUVr) scores. The maximum color (red) corresponds to an SUVr of approximately 2.2. The 4G8 immunohistochemistry shows precuneus gray matter with aggregated β-amyloid (red) using a
分子イメージング：新しいPET標識剤florbetapirによるアルツハイマー病のPET定量的診断・存在診断 | 内科開業医のお勉強日記
β-アミロイド斑を検知するPETスキャン造影剤である、Florbetapir 、これが、アルツハイマー病発症予測に役立つ Clark C, et al "Use of florbetapir-PET for imaging for beta-amyloid pathology" JAMA 2011; 305: 275-283. ピンシルバニア大学とAvid Radiopharmaceuticalsでかいハツされた、新しい18F 標識トレーサーで、βアミロイド会合体へ結合するが、CNS受容体やeurofibrillary tangleのような他の神経病態ターゲットへの結合しない。 研究では2つのコホートに分けて、35名の余命の少ない対象者（原文に書いてるからしょうがない）と74名の若年健康者で、10 mCiのflorbetapirを注入、30-50分後、10分間のPET検査 15/29（52
Selective neuronal damage and Wisconsin Card Sorting Test performance in atherosclerotic occlusive disease of the major cerebral artery
Selective neuronal damage and Wisconsin Card Sorting Test performance in atherosclerotic occlusive disease of the major cerebral artery Hiroshi Yamauchi1, Ryuichi Nishii2, Tatsuya Higashi2, Shinya Kagawa2, Hidenao Fukuyama11Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan2Research Institute, Shiga Medical Center, Moriyama, JapanCorrespondence to Dr Hiroshi Ya
Relationship between cerebral blood flow and later cognitive decline in hypertensive patients with cerebral small vessel disease - PubMed
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Cerebral blood flow measurement by PET in hypertensive subjects as a marker of cognitive decline - PubMed
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Discrimination of normal aging, MCI and AD with multimodal imaging measures on the medial temporal lobe - ScienceDirect
Discrimination of normal aging, MCI and AD with multimodal imaging measures on the medial temporal lobe This study aimed to compare the discrimination accuracy of hippocampal volume (HC-Vol), parahippocampal cingulum fractional anisotropy (PHC-FA), hippocampal glucose metabolism (HC-Glu), and any combination of the three measurements among normal control (NC), mild cognitive impairment (MCI), and
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A Diagnostic Approach in Alzheimer's Disease Using Three-Dimensional Stereotactic Surface Projections of Fluorine-18-FDG PET
https://jamanetwork.com/journals/jamaneurology/fullarticle/short/archneurol.2010.225v1