Post-Stroke Apathy and Hypoperfusion in Basal Ganglia: SPECT Study Onoda K.a · Kuroda Y.a · Yamamoto Y.c · Abe S.a · Oguro H.a · Nagai A.b · Bokura H.d · Yamaguchi S.a Author affiliations Departments of aNeurology and bLaboratory Medicine, Faculty of Medicine, Shimane University, cDepartment of Radiology, Shimane University Hospital, and dDepartment of Neurology, Shimane Prefectural Central Hospit

Changes in Vascular Risk Factors from Midlife to Late Life and White Matter Lesions: A 20-Year Follow-Up Study Vuorinen M.e · Solomon A.a, e · Rovio S.a · Nieminen L.e · Kåreholt I.a · Tuomilehto J.b–d · Soininen H.e–g · Kivipelto M.a, e Author affiliations aAging Research Center, NVS, Karolinska Institute, Stockholm, Sweden; bDepartment of Epidemiology and Health Promotion, National Public Health

Abstract Background/Aims: Raised low-grade systemic inflammation has been associated with dementia, and preliminary studies suggest an association with mild cognitive impairment (MCI). This study examines the relationship between systemic inflammation and MCI subtypes. Methods: We measured the inflammatory markers C-reactive protein, interleukins (IL)-1β, -6, -8, -10 and -12, plasminogen activator

Abstract Aims: We examined the individual association between body mass index (BMI) and cognitive function among the very elderly. Methods: The present study analyzed data from a survey that was conducted on all residents aged 90 years or more from a district which had 2,311,709 inhabitants in 2005. The subjects were divided into 4 groups according to quartiles of BMI (<16.6, 16.6–18.9, 18.9–21.1

Abstract Aims: Our purpose was to study the link between serum brain-derived neurotrophic factor (BDNF) levels and neuropsychological functioning through the Texas Alzheimer’s Research Consortium cohort. Methods: A total of 399 participants [probable Alzheimer’s disease (AD) n = 198, controls n = 201] were available for analysis. The BDNF levels were assayed via multiplex immunoassay. Regression a

Abstract Background: The Ε4 allele of apolipoprotein E (APOE) is associated with Alzheimer’s disease (AD). However, attributable risk due to APOE4 varies by region and by race/ethnicity. Methods: A literature review and meta-analysis were conducted to estimate the prevalence of APOE4 by geographic area among AD patients. Results: Although estimates varied significantly by study design and case def

Abdominal Fat, Adipose-Derived Hormones and Mild Cognitive Impairment: The J-SHIPP Study Kamogawa K.a · Kohara K.a, c · Tabara Y.b, c · Uetani E.a · Nagai T.a · Yamamoto M.a · Igase M.a · Miki T.a, c Author affiliations Departments of aGeriatric Medicine and bBasic Medical Research and Education, and cProteo-Medicine Research Center, Ehime University Graduate School of Medicine, Tõon, Japan

Prevalence of Mild Cognitive Impairment and Its Subtypes in the Heinz Nixdorf Recall Study Cohort Dlugaj M.a · Weimar C.a · Wege N.b · Verde P.E.c · Gerwig M.a · Dragano N.b · Moebus S.d · Jöckel K.-H.d · Erbel R.e · Siegrist J.b Author affiliations aDepartment of Neurology, University Hospital Essen, Essen, bDepartment of Medical Sociology and cCoordination Center for Clinical Trials, University

Generic and Disease-Specific Measures of Quality of Life in Patients with Mild Alzheimer’s Disease Bhattacharya S.a · Vogel A.a · Hansen M.-L.H.a · Waldorff F.B.a, b · Waldemar G.a Author affiliations aMemory Disorders Research Group, Department of Neurology, Neuroscience Centre, Copenhagen University Hospital, Rigshospitalet, and bResearch Unit and Department of General Practice, Institute of Pub

Diffusion Tensor Imaging Changes Correlate with Cognition Better than Conventional MRI Findings in Patients with Subcortical Ischemic Vascular Disease Xu Q.a, b · Zhou Y.c · Li Y.-S.b · Cao W.-W.b · Lin Y.b · Pan Y.-M.b · Chen S.-D.a Author affiliations aDepartment of Neurology, Ruijin Hospital, and Departments of bNeurology and cRadiology, Renji Hospital, Shanghai Jiao Tong University School of M

A Comparison of the Diagnostic Sensitivity of MRI, CBF-SPECT, FDG-PET and Cerebrospinal Fluid Biomarkers for Detecting Alzheimer’s Disease in a Memory Clinic Morinaga A.a, b · Ono K.a · Ikeda T.a · Ikeda Y.a · Shima K.a · Noguchi-Shinohara M.a, c · Samuraki M.a, d · Yanase D.a · Yoshita M.a · Iwasa K.a · Mastunari I.e · Yamada M.a Author affiliations aDepartment of Neurology and Neurobiology of Ag

Midlife Smoking, Apolipoprotein E and Risk of Dementia and Alzheimer’s Disease: A Population-Based Cardiovascular Risk Factors, Aging and Dementia Study Rusanen M.a, b · Rovio S.f · Ngandu T.a, c · Nissinen A.c · Tuomilehto J.c–e · Soininen H.a, b · Kivipelto M.a, f Author affiliations aDepartment of Neurology, University of Eastern Finland, and bDepartment of Neurology, Kuopio University Hospital

Executive Dysfunction and Left Frontal White Matter Hyperintensities Are Correlated with Neuropsychiatric Symptoms in Stroke Patients with Confluent White Matter Hyperintensities Mok V.C.T.a · Wong A.a · Wong K.d · Chu W.C.W.b · Xiong Y.a · Chan A.Y.Y.a · Kwok T.C.Y.a · Hu X.d · Lee W.K.b · Tang W.c · Wong K.L.a · Wong S.d Author affiliations Departments of aMedicine and Therapeutics, bRadiology a

The Influence of Vascular Disease on Cognitive Performance in the Preclinical and Early Phases of Alzheimer’s Disease Laukka E.J. · Fratiglioni L. · Bäckman L. Author affiliations

Phosphatidylserine Containing ω–3 Fatty Acids May Improve Memory Abilities in Non-Demented Elderly with Memory Complaints: A Double-Blind Placebo-Controlled Trial Vakhapova V.a · Cohen T.c · Richter Y.c · Herzog Y.c · Korczyn A.D.b Author affiliations aNeurology Department, Tel-Aviv Sourasky Medical Center, and bSieratzki Chair of Neurology, Tel-Aviv University Medical School, Tel-Aviv, and cEnzym