成人スティル病に対する抗IL-6抗体治療の有効性 | 内科開業医のお勉強日記
成人スティル病：adult Still's disease (ASD) 関連：ＡＯＳＤ：Adult-onset Still's disease（成人スティル病）：トルコの報告 2008-08-16 Tocilizumab in refractory adult Still's disease Arthritis Care & Research Volume 63, Issue 1, pages 155–159, January 2011 成人発症Still病に対し anti-interleukin (IL)-6 receptor antibody tocilizumab (Actemra) を投与すると、関節炎、全身症状が速やかに改善するという不応性患者の小グループ報告 14名のみの研究だが、疾患重症度として、２８関節(DAS28) の平均5.61から3.21へ3ヶ月で減少、6ヶ月で、2.
POS07 Reduced ADAMTS-13 activity levels in partial anterior circulation transient ischaemic attack patients compared to nonstroke controls
POS07 Reduced ADAMTS-13 activity levels in partial anterior circulation transient ischaemic attack patients compared to nonstroke controls G A Frentzou, C Kamara, K A Harkness, G Haddock, C Doyle, M Taylor, G S Venables, M N Woodroofe, A K Cross, M RandallSheffield Hallam University, Sheffield, UKCorrespondence to G.Frentzou{at}shu.ac.uk AbstractClarification of the pathophysiological mechanisms o
システマティックレビュー：シェーグレン症候群の治療 | 内科開業医のお勉強日記
Treatment of Primary Sjögren Syndrome A Systematic Review Manuel Ramos-Casals, MD, PhD; Athanasios G. Tzioufas, MD; John H. Stone, MD, MPH; Antoni Sisó, MD, PhD; Xavier Bosch, MD, PhD JAMA. 2010;304(4):452-460. doi:10.1001/jama.2010.1014 ・シクロスポリン0.05％局所点眼 ・pilocarpine ・cevimeline ・hydroxychloroquine ・免疫抑制剤：azathioprine、cyclopsporine ・経口interferon alfa-2a ・infliximab、etanercept ・rituximab 以上が、書かれてい
悪性リンパ腫：慢性炎症が引き金 東大チーム解明 - 毎日ｊｐ(毎日新聞)
血液がんの一種の悪性リンパ腫が起きる仕組みを、小川誠司・東京大病院特任准教授（血液腫瘍（しゅよう）学）らが解明し、４日付の英科学誌ネイチャー電子版に発表した。一部の悪性リンパ腫では、胃炎など慢性的な炎症が引き金だった。炎症抑制が悪性リンパ腫の治療につながる可能性を示す成果として注目されそうだ。【西川拓】 悪性リンパ腫は、免疫機能を担うリンパ球にできるがんで、国内で年約８５００人死亡している。 研究チームは、遺伝子を構成する物質「塩基」の配列の個人差を高効率で検出する技術を開発、悪性リンパ腫患者約３００人で調べた。すると、主に消化管にできる「マルトリンパ腫」など２種類の悪性リンパ腫では、約２割の患者が、遺伝子Ａ２０の配列に変異があり働いていなかった。 この遺伝子は、炎症発生時にリンパ球が際限なく増殖しないようブレーキ役となっている。Ａ２０が働かない悪性リンパ腫細胞をマウスに移植すると、リンパ
Hashimot's encephalopathy-response to intravenous immunoglobulin - PubMed
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NMO-IgGが血清で陰性，髄液で陽性というケース - Neurology 興味を持った「脳神経内科」論文
NMO spectrum disorderが疑われたものの，血清NMO-IgGが陰性で，髄液NMO-IgGのみ陽性であった3症例のcase seriesが報告されている（Washington Universityからの報告）．いずれの症例も急性に発症する縦長の横断性脊髄病変を呈したが，頭部MRIは正常で，視神経炎の合併も認めなかった．いずれも発症2年以内で，初発から数か月以内に生じた2度目の再発は重症であった．血清では3例とも120倍希釈で陰性であったが，同時に施行した髄液の測定では陽性であった（いずれもMayo Medical Laboratoriesで行った）．いずれも症例もAlb indexは正常で，血液脳関門は保たれていると考えられた． Discussionの中で，もし血清NMO-IgGが陰性であっても，臨床的にNMO spectrum disorderを疑う以下のような病態を呈し
Anti-Hu-associated brainstem encephalitis
A Saiz1, J Bruna2, P Stourac3, M C Vigliani4, B Giometto5, W Grisold6, J Honnorat7, D Psimaras8, R Voltz9, F Graus11Service of Neurology, Institut d’Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain 2Service of Neurology, Hospital Universitari de Bellvitge, Hospitalet, Barcelona, Spain 3Department of Neurology, Masaryk University, Brno, Czech Republic 4Departme
Effect of infliximab in progressive neuro-Behçet's syndrome - PubMed
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Neuro-Behçet disease with demyelination and gliosis of the frontal white matter - PubMed
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Brain SPECT with neuro-Behçet disease - PubMed
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Mutism developing after bilateral thalamo-capsular lesions by neuro-Behçet disease - PubMed
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Neuropsychological follow-up of 12 patients with neuro-Behçet disease - PubMed
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Diffusion-weighted imaging in chronic Behçet patients with and without neurological findings - PubMed
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Clinicopathological study on a case of neuro-Behçet's disease: in special reference to MRI, SPECT and neuropathological findings - PubMed
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Delayed diagnosis of a neuroBehçet patient with only brainstem and cerebellar atrophy: literature review - PubMed
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Cognitive impairment in Behçet's disease patients without overt neurological involvement - PubMed
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MRI findings in neuro-behçet's disease - PubMed
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Technetium-99m-HMPAO SPECT and MRI of brain in patients with neuro-Behçet's syndrome - PubMed
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Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study: a case-control study
特殊型ベーチェットに対する生物学的製剤治療の可能性
