Chemogenetics revealed: DREADD occupancy and activation via converted clozapine View ORCID ProfileJuan L. Gomez1,*, View ORCID ProfileJordi Bonaventura1,*, View ORCID ProfileWojciech Lesniak2, View ORCID ProfileWilliam B. Mathews2, View ORCID ProfilePolina Sysa-Shah2, View ORCID ProfileLionel A. Rodriguez1, Randall J. Ellis1, View ORCID ProfileChristopher T. Richie3, View ORCID ProfileBrandon K. H

SummaryMore than 30,000 people have disappeared without a trace in Mexico, most since violence skyrocketed after the government began battling drug cartels in 2006. Police investigations rarely solve such crimes, so many families are left to search on their own for the hidden graves that may hold their relatives. Last week, a team of data scientists and human rights researchers released a new tool

Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems Keiji Nishida1, Takayuki Arazoe1, Nozomu Yachie2,3,4, Satomi Banno1, Mika Kakimoto1, Mayura Tabata1, Masao Mochizuki1, Aya Miyabe1, Michihiro Araki1, Kiyotaka Y. Hara5, Zenpei Shimatani1, Akihiko Kondo1,6,*1Graduate School of Science, Technology and Innovation, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Ko

Clyde A. Hutchison III1,*,†, Ray-Yuan Chuang1,†,‡, Vladimir N. Noskov1, Nacyra Assad-Garcia1, Thomas J. Deerinck2, Mark H. Ellisman2, John Gill3, Krishna Kannan3, Bogumil J. Karas1, Li Ma1, James F. Pelletier4,§, Zhi-Qing Qi3, R. Alexander Richter1, Elizabeth A. Strychalski4, Lijie Sun1,||, Yo Suzuki1, Billyana Tsvetanova3, Kim S. Wise1, Hamilton O. Smith1,3, John I. Glass1, Chuck Merryman1, Danie

Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction Yasuhiro Yamauchi1,*, Jonathan M. Riel1,*, Victor A. Ruthig1,*, Eglė A. Ortega1, Michael J. Mitchell2, Monika A. Ward1,†1Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, 1960 East-West Road, Honolulu, HI 96822, USA.2Aix-Marseille Université, INSERM, GMGF UMR_S 910, 13385 M

Exposure to ideologically diverse news and opinion on Facebook Eytan Bakshy1,*,†, Solomon Messing1,†, Lada A. Adamic1,21Facebook, Menlo Park, CA 94025, USA.2School of Information, University of Michigan, Ann Arbor, MI, USA.↵*Corresponding author. E-mail: ebakshy{at}fb.com↵† These authors contributed equally to this work.