Sagittal and axial views of positron emission tomographic (PET) scans of representative patients. The vertical bars indicate the range of semiautomated quantitative analysis of the ratio of cortical to cerebellar signal (SUVr) scores. The maximum color (red) corresponds to an SUVr of approximately 2.2. The 4G8 immunohistochemistry shows precuneus gray matter with aggregated β-amyloid (red) using a

β-アミロイド斑を検知するPETスキャン造影剤である、Florbetapir 、これが、アルツハイマー病発症予測に役立つ Clark C, et al "Use of florbetapir-PET for imaging for beta-amyloid pathology" JAMA 2011; 305: 275-283. ピンシルバニア大学とAvid Radiopharmaceuticalsでかいハツされた、新しい18F 標識トレーサーで、βアミロイド会合体へ結合するが、CNS受容体やeurofibrillary tangleのような他の神経病態ターゲットへの結合しない。 研究では2つのコホートに分けて、35名の余命の少ない対象者（原文に書いてるからしょうがない）と74名の若年健康者で、10 mCiのflorbetapirを注入、30-50分後、10分間のPET検査 15/29（52

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As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Alzheimer Dis Assoc Disord. Author manuscript; available in PMC 2010 May 6.

AbstractBACKGROUND AND PURPOSE: Cerebral hemodynamics abnormality in Alzheimer disease (AD) is not fully understood. Our aim was to determine whether regional hypoperfusion due to AD is associated with abnormalities in regional arterial blood volume (rABV) and regional arterial transit time (rATT) as measured by quantitative arterial spin-labeling (ASL) with multiple-delay time sampling. MATERIALS

Example white matter hyperintensity (WMH) detection results for 3 individuals whose WMH distributions are representative of the broader sample. Detected WMHs are overlaid in white on slices of T1-weighted images. Each row shows a set of 3 slices for a given individual. Each column shows detection at an analogous slice across all 3 individuals. The 3 individuals differ in their WMH distribution: th

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Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis