Simultaneous Measurement of Arterial Transit Time, Arterial Blood Volume, and Cerebral Blood Flow Using Arterial Spin-Labeling in Patients with Alzheimer Disease

AbstractBACKGROUND AND PURPOSE: Cerebral hemodynamics abnormality in Alzheimer disease (AD) is not fully understood. Our aim was to determine whether regional hypoperfusion due to AD is associated with abnormalities in regional arterial blood volume (rABV) and regional arterial transit time (rATT) as measured by quantitative arterial spin-labeling (ASL) with multiple-delay time sampling. MATERIALS

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MRI ASLでAD患者のCBF、ATT(arterial transit time)、ABV(arterial blood volume)を測定。ADではCBFは低下していたが、ATTは有意差なくABVはむしろ低値な傾向。CVDとはCBF低下が別機序により発生する可能性。

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MRI ASLでAD患者のCBF、ATT(arterial transit time)、ABV(arterial blood volume)を測定。ADではCBFは低下していたが、ATTは有意差なくABVはむしろ低値な傾向。CVDとはCBF低下が別機序により発生する可能性。