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Abstract Aims: We examined the individual association between body mass index (BMI) and cognitive function among the very elderly. Methods: The present study analyzed data from a survey that was conducted on all residents aged 90 years or more from a district which had 2,311,709 inhabitants in 2005. The subjects were divided into 4 groups according to quartiles of BMI (<16.6, 16.6–18.9, 18.9–21.1

ベースライン認知症無しの老人の前向きコホート研究で、Yaffeらは、1年次の低血中β-アミロイド42/40が9年後の認知症減少と関連することを見いだした。 Bretelerは、これが認知機能減弱と、アルツハイマー病のバイオマーカーとして有望か議論 Association of Plasma β-Amyloid Level and Cognitive Reserve With Subsequent Cognitive Decline JAMA. 2011;305(3):261-266. 髄液では以下の報告などがあるようだ Prediction of Alzheimer’s Disease Using the CSF Aβ42/Aβ40 Ratio in Patients with Mild Cognitive Impairment Dementia and geriatric cogniti

Figure. Multivariate Mixed-Effects Model for Adjusted Mean 3MS Score by Years of Follow-up, Education/Literacy Level, and β-Amyloid 42/40 High/Low Tertiles 3MS indicates Modified Mini-Mental State Examination. Error bars indicate 95% confidence intervals (CIs). A, For education level, models are adjusted for age, race, diabetes, smoking, and apolipoprotein E (APOE) e4 status; the interaction term

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

The Journal of Neuroscience　12月15日号記載らしい 報道記事：MRI scans reveal brain changes in people at genetic risk for Alzheimer’s APOE4 genotype linked to functional changes prior to formation of senile plaques http://news.wustl.edu/news/Pages/21633.aspx apolipoprotein E (APOE) 遺伝子、APOE4変異の有無にて、fMRIによる脳でのconncectivityの減少領域を示すという改めて視覚的に確認の報告。 Reprinted with permission: Sheline, et al. The Journal of Neuroscie

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As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Alzheimer Dis Assoc Disord. Author manuscript; available in PMC 2010 May 6.