APOE4遺伝子変異有無による脳内connectivity比較 | 内科開業医のお勉強日記
The Journal of Neuroscience 12月15日号記載らしい 報道記事：MRI scans reveal brain changes in people at genetic risk for Alzheimer’s APOE4 genotype linked to functional changes prior to formation of senile plaques http://news.wustl.edu/news/Pages/21633.aspx apolipoprotein E (APOE) 遺伝子、APOE4変異の有無にて、fMRIによる脳でのconncectivityの減少領域を示すという改めて視覚的に確認の報告。 Reprinted with permission: Sheline, et al. The Journal of Neuroscie
Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI
Abstract Objectives: To test if arterial spin labeling (ASL) MRI could detect a pattern of hypoperfusion in frontotemporal dementia (FTD) vs cognitively normal (CN) control subjects; to determine the regional difference of perfusion between FTD and Alzheimer disease (AD); and to determine whether hypoperfusion in FTD correlates with cognitive impairment. Methods: We included 21 patients with FTD,
Arch Neurol -- Abstract: Longitudinal Changes in White Matter Disease and Cognition in the First Year of the Alzheimer Disease Neuroimaging Initiative, November 2010, Carmichael et al. 67 (11): 1370
Example white matter hyperintensity (WMH) detection results for 3 individuals whose WMH distributions are representative of the broader sample. Detected WMHs are overlaid in white on slices of T1-weighted images. Each row shows a set of 3 slices for a given individual. Each column shows detection at an analogous slice across all 3 individuals. The 3 individuals differ in their WMH distribution: th
Relationship between cerebral blood flow and later cognitive decline in hypertensive patients with cerebral small vessel disease - PubMed
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Automated Discrimination Between Very Early Alzheimer Disease and Controls Using an Easy Z-Score Imaging System for Multicenter Brain Perfusion Single-Photon Emission Tomography
AbstractBACKGROUND AND PURPOSE: In Alzheimer disease (AD), a peculiar regional cerebral blood flow (rCBF) abnormality has been reported in the posterior cingulate gyri and precunei, even at a very early stage. We performed a multicenter brain perfusion single-photon emission tomography (SPECT) study to evaluate the discrimination ability of an easy Z-score imaging system (eZIS) with a common norma
Diffusion Tensor Imaging Changes Correlate with Cognition Better than Conventional MRI Findings in Patients with Subcortical Ischemic Vascular Disease
Diffusion Tensor Imaging Changes Correlate with Cognition Better than Conventional MRI Findings in Patients with Subcortical Ischemic Vascular Disease Xu Q.a, b · Zhou Y.c · Li Y.-S.b · Cao W.-W.b · Lin Y.b · Pan Y.-M.b · Chen S.-D.a Author affiliations aDepartment of Neurology, Ruijin Hospital, and Departments of bNeurology and cRadiology, Renji Hospital, Shanghai Jiao Tong University School of M
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Discrimination of normal aging, MCI and AD with multimodal imaging measures on the medial temporal lobe - ScienceDirect
Discrimination of normal aging, MCI and AD with multimodal imaging measures on the medial temporal lobe This study aimed to compare the discrimination accuracy of hippocampal volume (HC-Vol), parahippocampal cingulum fractional anisotropy (PHC-FA), hippocampal glucose metabolism (HC-Glu), and any combination of the three measurements among normal control (NC), mild cognitive impairment (MCI), and
ＭＲＩ大脳白質病変は卒中・認知症・死亡リスクと関連 | 内科開業医のお勉強日記
私は、「無症候性脳梗塞・隠れ梗塞」などＭＲＩにより作成された”病気”のその意義に懐疑的。 今回明らかとなった”大脳白質病変”の存在が、その後の認知症・卒中・死亡と関連したという所見は重要だが、「白質病変・・・即、何らかの治療」ということではない・・・と思う。 MRIによるWhite matter hyperintensity(大脳白質病変)から卒中、認知症、死亡リスク増加が予測される。故に、診断検査の一部として、脳血管イベントリスク増加を示唆するものであり、研究の分野で介在マーカーとしての役割を支持する。 この知見が、卒中・認知症のスクリーニングの至適な詳細化につながることを期待する 卒中 認知症 死亡 The clinical importance of white matter hyperintensities on brain magnetic resonance imaging:
White matter changes and diabetes predict cognitive decline in the elderly: The LADIS Study -- Verdelho et al. 75 (2): 160 -- Neurology
The LADIS Study A. Verdelho, MD, S. Madureira, PsyD, C. Moleiro, PsyD, PhD, J.M. Ferro, MD, PhD, C.O. Santos, PsyD, T. Erkinjuntti, MD, PhD, L. Pantoni, MD, PhD, F. Fazekas, MD, M. Visser, MD, PhD, G. Waldemar, MD, DMSc, A. Wallin, MD, PhD, M. Hennerici, MD, D. Inzitari, MD On behalf of the LADIS Study From the Neurosciences Department (A.V., S.M., J.M.F., C.O.S.), Lisbon University, Santa Maria H
Serial MRI and CSF biomarkers in normal aging, MCI, and AD -- Vemuri et al. 75 (2): 143 -- Neurology
P. Vemuri, PhD, H.J. Wiste, BA, S.D. Weigand, MS, D.S. Knopman, MD, J.Q. Trojanowski, MD, PhD, L.M. Shaw, PhD, M.A. Bernstein, PhD, P.S. Aisen, MD, M. Weiner, MD, R.C Petersen, MD, PhD, C.R Jack, Jr., MD On behalf of the Alzheimer's Disease Neuroimaging Initiative From the Aging and Dementia Imaging Research Laboratory, Department of Radiology (P.V., M.A.B., C.R.J.), Health Sciences Research (H.J.
Alzheimer disease identification using amyloid imaging and reserve variables: Proof of concept -- Roe et al. 75 (1): 42 -- Neurology
Proof of concept C.M. Roe, PhD, M.A. Mintun, MD, N. Ghoshal, MD, PhD, M.M. Williams, MD, E.A. Grant, PhD, D.S. Marcus, PhD and J.C. Morris, MD From the Alzheimer's Disease Research Center (C.M.R., M.A.M., N.G., M.M.W., E.A.G., D.S.M., J.C.M.), Departments of Neurology (C.M.R., N.G., J.C.M.), Radiology (M.A.M., D.S.M.), Medicine (M.M.W.), Psychiatry (M.M.W.), Pathology and Immunology (J.C.M.), Phys
A diffusion tensor MRI study of patients with MCI and AD with a 2-year clinical follow-up
A diffusion tensor MRI study of patients with MCI and AD with a 2-year clinical follow-up Elisa Scola1, Marco Bozzali2, Federica Agosta3, Giuseppe Magnani4, Massimo Franceschi5, Maria Pia Sormani3,6, Mara Cercignani7, Elisabetta Pagani3, Monica Falautano4, Massimo Filippi3, Andrea Falini11Neuroradiology Unit and CERMAC, Scientific Institute and University Ospedale San Raffaele, Milan, Italy2Neuroi
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00334-0%2Fabstract)
Comparison of regional cerebral blood flow in two subsets of subcortical ischemic vascular dementia: Statistical parametric mapping analysis of SPECT
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Analysis of cerebral blood flow of subcortical vascular dementia with single photon emission computed tomography
ASL Perfusion MRI Predicts Cognitive Decline and Conversion From MCI to Dementia
https://www.ahajournals.org/doi/abs/10.1161/strokeaha.110.587717?rss=1
Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis
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Predictors and assessment of cognitive dysfunction resulting from ischaemic stroke
頭部MRIの高信号域は脳卒中や認知症リスクを予測する
