APOE4遺伝子変異有無による脳内connectivity比較 | 内科開業医のお勉強日記
The Journal of Neuroscience 12月15日号記載らしい 報道記事：MRI scans reveal brain changes in people at genetic risk for Alzheimer’s APOE4 genotype linked to functional changes prior to formation of senile plaques http://news.wustl.edu/news/Pages/21633.aspx apolipoprotein E (APOE) 遺伝子、APOE4変異の有無にて、fMRIによる脳でのconncectivityの減少領域を示すという改めて視覚的に確認の報告。 Reprinted with permission: Sheline, et al. The Journal of Neuroscie
ASL Perfusion MRI Predicts Cognitive Decline and Conversion From MCI to Dementia
As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Alzheimer Dis Assoc Disord. Author manuscript; available in PMC 2010 May 6.
Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI
Abstract Objectives: To test if arterial spin labeling (ASL) MRI could detect a pattern of hypoperfusion in frontotemporal dementia (FTD) vs cognitively normal (CN) control subjects; to determine the regional difference of perfusion between FTD and Alzheimer disease (AD); and to determine whether hypoperfusion in FTD correlates with cognitive impairment. Methods: We included 21 patients with FTD,
Arch Neurol -- Abstract: Longitudinal Changes in White Matter Disease and Cognition in the First Year of the Alzheimer Disease Neuroimaging Initiative, November 2010, Carmichael et al. 67 (11): 1370
Example white matter hyperintensity (WMH) detection results for 3 individuals whose WMH distributions are representative of the broader sample. Detected WMHs are overlaid in white on slices of T1-weighted images. Each row shows a set of 3 slices for a given individual. Each column shows detection at an analogous slice across all 3 individuals. The 3 individuals differ in their WMH distribution: th
PATH56 MRI correlates of vascular cognitive impairment: contribution of microbleeds, white matter changes and infarcts in a large hospital-based cross-sectional study
PATH56 MRI correlates of vascular cognitive impairment: contribution of microbleeds, white matter changes and infarcts in a large hospital-based cross-sectional study S Gregoire, L Cipolotti, N Sokolovsky, M M Brown, T A Yousry, D J Werring, H R Jaeger, K Smith, K Oaksford, G SchefflerUCL Institute of Neurology, London, UKCorrespondence to s.gregoire{at}ion.ucl.ac.uk Background The mechanisms unde
Psychiatry Research: Neuroimaging | Journal | ScienceDirect.com by Elsevier
Psychiatry Research: Neuroimaging, a companion title to Psychiatry Research, focuses on publications relating to imaging techniques. We publish manuscripts on magnetic resonance imaging, positron emission tomography, multichannel electrophysiology, near-infrared spectroscopy, computed tomography, magnetoencephalography, non-invasive brain stimulation, autoradiography, post-mortem regional analyses
Diffusion Tensor Imaging Changes Correlate with Cognition Better than Conventional MRI Findings in Patients with Subcortical Ischemic Vascular Disease
Diffusion Tensor Imaging Changes Correlate with Cognition Better than Conventional MRI Findings in Patients with Subcortical Ischemic Vascular Disease Xu Q.a, b · Zhou Y.c · Li Y.-S.b · Cao W.-W.b · Lin Y.b · Pan Y.-M.b · Chen S.-D.a Author affiliations aDepartment of Neurology, Ruijin Hospital, and Departments of bNeurology and cRadiology, Renji Hospital, Shanghai Jiao Tong University School of M
Progression of brain atrophy and cognitive decline in diabetes mellitus: A 3-year follow-up -- van Elderen et al. 75 (11): 997 -- Neurology
A 3-year follow-up S.G.C. van Elderen, MD, A. de Roos, MD, A.J.M. de Craen, PhD, R.G.J. Westendorp, MD, G.J. Blauw, MD, J.W. Jukema, MD, E.L.E.M. Bollen, MD, H.A.M. Middelkoop, MD, M.A. van Buchem, MD and J. van der Grond, PhD From the Departments of Radiology (S.G.C.v.E., A.d.R., M.A.v.B., J.v.d.G.), Gerontology and Geriatrics (A.J.M.d.C., R.G.J.W., G.J.B.), Cardiology (J.W.J.), and Neurology (E.
Discrimination of normal aging, MCI and AD with multimodal imaging measures on the medial temporal lobe - ScienceDirect
Discrimination of normal aging, MCI and AD with multimodal imaging measures on the medial temporal lobe This study aimed to compare the discrimination accuracy of hippocampal volume (HC-Vol), parahippocampal cingulum fractional anisotropy (PHC-FA), hippocampal glucose metabolism (HC-Glu), and any combination of the three measurements among normal control (NC), mild cognitive impairment (MCI), and
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Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis
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Predictors and assessment of cognitive dysfunction resulting from ischaemic stroke
頭部MRIの高信号域は脳卒中や認知症リスクを予測する