If you transmit a number whereas an integer encoded on 64 bits is expected you will get an exception: let run = async () => { try { let bytecode = await fetch("add/add.wasm"); let wasm = await WebAssembly.instantiateStreaming(bytecode); console.log(wasm.instance.exports.addInt64(1,2)); } catch(e) { console.error(e); } }; > run().then(); TypeError: wasm function signature contains illegal type Call