トリンテリックスという新しいタイプの抗うつ剤が発売された その１ : 場末Ｐ科病院の精神科医のblog
2月1 トリンテリックスという新しいタイプの抗うつ剤が発売された その１ カテゴリ:抗うつ剤うつ病 昨年の秋に、久々に新しいタイプの抗うつ剤が国内で承認された。トリンテリックス（ボルチオキセチン、Vortioxetine)である。 発売元のタケダ薬品のホームページには以下のような案内がなされている。https://www.takeda.com/ja-jp/announcements/2019/trintellix/ 武田薬品は、ボルチオキセチンが、うつ病の症状をプラセボと比較して統計学的に有意に改善したことを示す国内臨床第3相試験（NCT02389816）などの結果を基に、2018年9月に厚生労働省に製造販売承認申請を行い、2019年9月20日に製造販売承認を取得しました。本剤は、セロトニン再取り込み阻害作用ならびにセロトニン受容体調節作用といった複数の薬理作用を併せもつ国内で承認を取得し
Suicidal thoughts and behavior with antidepressant treatment: reanalysis of the randomized placebo-controlled studies of fluoxetine and venlafaxine - PubMed
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Can people with nonsevere major depression benefit from antidepressant medication? - PubMed
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Differential effectiveness of newer and older antidepressants appears mediated by an age effect on the phenotypic expression of depression - PubMed
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Duloxetine-bupropion combination for treatment-resistant atypical depression: a double-blind, randomized, placebo-controlled trial - PubMed
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Double-blind, placebo-controlled evaluation of extended-release bupropion in elderly patients with major depressive disorder - PubMed
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Efficacy and tolerability of antidepressants in people aged 65 years or older with major depressive disorder - A systematic review and a meta-analysis - PubMed
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Does collaborative care improve social functioning in adults with depression? The application of the WHO ICF framework and meta-analysis of outcomes - PubMed
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Effect of antidepressant treatment on cognitive impairments associated with depression: a randomised longitudinal study - PubMed
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Efficacy of duloxetine on cognition, depression, and pain in elderly patients with major depressive disorder: an 8-week, double-blind, placebo-controlled trial - PubMed
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A double-blind, placebo-controlled study of venlafaxine and fluoxetine in geriatric outpatients with major depression - PubMed
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Comparison of venlafaxine alone versus venlafaxine plus bright light therapy combination for severe major depressive disorder - PubMed
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A review of the use of stimulants and stimulant alternatives in treating bipolar depression and major depressive disorder - PubMed
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Diagnosing bipolar disorder and the effect of antidepressants: a naturalistic study - PubMed
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Paroxetine versus other anti-depressive agents for depression - PubMed
Paroxetine versus other anti-depressive agents for depression - PubMed
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Tianeptine therapy for depression in the elderly - PubMed