Get difference between two lists with Unique Entries

I have two lists in Python: temp1 = ['One', 'Two', 'Three', 'Four'] temp2 = ['One', 'Two'] Assuming the elements in each list are unique, I want to create a third list with items from the first list which are not in the second list: temp3 = ['Three', 'Four'] Are there any fast ways without cycles and checking?