Direct Conversion of Normal and Alzheimer’s Disease Human Fibroblasts into Neuronal Cells by Small Molecules

[frothmouth]

“Highlights•Human fibroblasts can be directly converted into neurons with a chemical cocktail•Electrophysiological properties of hciNs are similar to iPSC-derived neurons and iNs•hciNs show high neuronal but low fibroblastic gene expression profiles•hciNs derived from FAD patient fibroblas