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Your smartphone and laptop are made of electronic circuits. Genetic circuits, modelled on the electronic ones, are human-designed combinations of genetic components that interact to produce one or more proteins or RNA molecules, for example, in response to a given stimulus, such as a toxin. Under the right conditions, the circuit might be triggered to make “protein A, which then interacts with pro
China has announced tough new rules to beat research fraud.Credit: Anthony Kwan/Bloomberg/Getty The Chinese government knows that a slice of its generous science budget — the world’s second-largest by country — goes to waste on bad science. It doesn’t want to waste any more. On 30 May, the State Council and the Communist Party of China announced a radical new system of regulations to police scienc
Total RNA sequencing (total RNA-seq) provides rich information on biological systems in addition to the abundance of mRNAs. First, total RNA-seq can measure not only poly(A) but also non-poly(A) RNAs, including nascent RNAs, histone mRNAs, long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), and enhancer RNAs (eRNAs)1,2,3,4,5,6,7. Non-poly(A) RNAs are dynamically regulated and involved in impo
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