Topological domains in mammalian genomes identified by analysis of chromatin interactions - Nature
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BioTechniques - 5-hmC, Not Just an Intermediate
New evidence suggests that the 5hmC epigenetic mark has a distinct role in neurodevelopment, adding to the list of possible functional roles for this epigenetic modification. Andrew Wiecek looks at how this new piece of information fits into the emerging picture of 5hmC function. When researchers first identified 5-hydroxymethylcytosine (5hmC) in mammalian cells in 2009 (1-2), confusion was the or
BioTechniques - Future Methods for Epigenetic Studies
BioTechniques spoke with Charles Epstein, Paul Soloway, and Mazhar Adli about the current bottlenecks and developing technologies in the field of epigenetics. In our 2011 Future Methods article series, BioTechniques presents in-depth interviews with the thought-leaders and methods developers in the fields of cell biology, genomics, proteomics, epigenetics, and microfluidics. These articles will pr
BioTechniques - Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA
DNA cytosine methylation (5mC) is highly abundant in mammalian cells and is associated with transcriptional repression. Recently, hydroxymethylcytosine (hmC) has been detected at high levels in certain human cell types; however, its roles are unknown. Due to the structural similarity between 5mC and hmC, it is unclear whether 5mC analyses can discriminate between these nucleotides. Here we show th
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Mapping and analysis of chromatin state dynamics in nine human cell types
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BioTechniques - 5hmC Comes into Focus
A unique regulatory phase of DNA methylation in the early mammalian embryo - Nature
Bisulphite-sequencing of chromatin immunoprecipitated DNA (BisChIP-seq) directly informs methylation status of histone-modified DNA
Picking ChIP-seq peak detectors for analyzing chromatin modification experiments
DNA-binding factors shape the mouse methylome at distal regulatory regions - Nature
http://www.nature.com/nature/journal/v479/n7373/abs/nature10572_ja.html
Global DNA Demethylation During Mouse Erythropoiesis in Vivo | Science
BioTechniques - 5-hmC, Not Just an Intermediate
BioTechniques - Epigenomics at Base-Pair Resolution
BioTechniques - Finding hmC
Transgenerational Epigenetic Instability Is a Source of Novel Methylation Variants | Science
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells - Nature
卵母細胞によるエピジェネティックな再プログラム化にDNAジオキシゲナーゼTet3が果たす役割 : Nature : Nature Publishing Group
Large-scale methylation domains mark a functional subset of neuronally expressed genes