BioTechniques - 5-hmC, Not Just an Intermediate
New evidence suggests that the 5hmC epigenetic mark has a distinct role in neurodevelopment, adding to the list of possible functional roles for this epigenetic modification. Andrew Wiecek looks at how this new piece of information fits into the emerging picture of 5hmC function. When researchers first identified 5-hydroxymethylcytosine (5hmC) in mammalian cells in 2009 (1-2), confusion was the or
BioTechniques - Google to the Rescue
Last spring, the NIH announced plans to shut down its DNA sequence data archive. Now, Google has stepped in to make sure that data remains available to researchers. Thanks to Google, the next-generation sequencing database that was scheduled to be shut down by the government earlier this year due to budget constraints will continue to be available to researchers. Last spring, the National Institut
BioTechniques - Future Methods for Epigenetic Studies
BioTechniques spoke with Charles Epstein, Paul Soloway, and Mazhar Adli about the current bottlenecks and developing technologies in the field of epigenetics. In our 2011 Future Methods article series, BioTechniques presents in-depth interviews with the thought-leaders and methods developers in the fields of cell biology, genomics, proteomics, epigenetics, and microfluidics. These articles will pr
BioTechniques - Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA
DNA cytosine methylation (5mC) is highly abundant in mammalian cells and is associated with transcriptional repression. Recently, hydroxymethylcytosine (hmC) has been detected at high levels in certain human cell types; however, its roles are unknown. Due to the structural similarity between 5mC and hmC, it is unclear whether 5mC analyses can discriminate between these nucleotides. Here we show th
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http://www.biotechniques.com/news/Solar-PCR-Theres-an-App-for-That/biotechniques-351006.html
BioTechniques - RNA-seq Showdown
http://www.biotechniques.com/news/NIH-Invests-90M-in-Single-Cell-Analysis/biotechniques-336364.html
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BioTechniques - 5-hmC, Not Just an Intermediate
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BioTechniques - Finding hmC
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