Frontostriatal salience network expansion in individuals in depression - Nature

Depression is a heterogeneous and episodic neuropsychiatric syndrome associated with synapse loss5,6 and connectivity alterations in frontostriatal networks7,8,9 and a leading cause of disability worldwide10. The neurobiological mechanisms that give rise to specific depressive symptom domains or to changes in mood over time are not well understood, especially at the neural systems level. So far, m