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AlphaFold3 can predict the structures of proteins as they interact with DNA.Credit: Werel et al./American Society for Microbiology, Mol*, RCSB PDB AlphaFold3 is open at last. Six months after Google DeepMind controversially withheld code from a paper describing the protein-structure prediction model1, scientists can now download the software code and use the artificial intelligence (AI) tool for n
Despite many seeing the result as a step backwards, the research community should engage with the new administration with courage, tenacity, strength and unity. Moving on: Donald Trump’s re-election poses challenges for science.Credit: Loren Elliott/Getty When Donald Trump was first elected to the US presidency in 2016, Nature advised scientists to constructively engage with Trump. We said that th
After graduating from the medical and biological illustration programme at Johns Hopkins University in Baltimore, Maryland, Shiz Aoki fulfilled a long-held dream: she launched her own company. Founded in 2010 in Toronto, Canada, Anatomize Studios works with large clients — pharmaceutical companies, magazines and medical professionals with niche needs and capacious budgets. Yet Aoki would often als
As digital devices and the Internet become integral parts of daily life, concerns about their potential negative impact on human well-being, especially that of prolonged screen time, have become more pronounced. Video games, at the forefront of this debate, increasingly encounter public scepticism1. Controversial health policy decisions, such as the latest discussions by the World Health Organizat
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The development of LLMs is very involved and requires large quantities of training data. Yet, although current LLMs2,4,5,6, including GPT-3, were trained on predominantly human-generated text, this may change. If the training data of most future models are also scraped from the web, then they will inevitably train on data produced by their predecessors. In this paper, we investigate what happens w
While conspiracy theories are not new1,2, recent events have shown how dangerous and polarizing they can be in a globalized, mediatized world. Conspiracy theories undermined global efforts to contain the COVID-19 virus during the pandemic3,4 and were used in the lead-up to the January 6, 2021, raid on the Capitol1. They lie at the core of political and social polarization5,6, fueling vaccine skept
Barham, L. & Everett, D. Semiotics and the origin of language in the Lower Palaeolithic. J. Archaeol. Method Theory 28, 535–579 (2021). Article Google Scholar Hockett, C. F. The origin of speech. Sci. Am. 203, 88–97 (1960). A classic overview of the relationship between key features of human language and communication systems found in other species, with a focus on distinctive and shared propertie
Predicting and understanding food perception and appreciation is one of the major challenges in food science. Accurate modeling of food flavor and appreciation could yield important opportunities for both producers and consumers, including quality control, product fingerprinting, counterfeit detection, spoilage detection, and the development of new products and product combinations (food pairing)1
Main1,2. ARDS due to COVID-19 has been associated with encephalopathy, agitation, confusion and corticospinal tract dysfunction. Such symptoms, however, including anosmia (although not to the extent seen in the first wave of COVID-19), may be expected in anyone recovering from a severe viral illness because of cytokine release, critical illness encephalopathy or medication3. Neurological sequelae
DNA sequencing has become routine, but the roles of individual genes can be hard to be pin.Credit: Peter Menzel/SPL How Life Works: A User’s Guide to the New Biology Philip Ball Pan Macmillan (2024) For too long, scientists have been content in espousing the lazy metaphor of living systems operating simply like machines, says science writer Philip Ball in How Life Works. Yet, it’s important to be
Proving theorems showcases the mastery of logical reasoning and the ability to search through an infinitely large space of actions towards a target, signifying a remarkable problem-solving skill. Since the 1950s (refs. 6,7), the pursuit of better theorem-proving capabilities has been a constant focus of artificial intelligence (AI) research8. Mathematical olympiads are the most reputed theorem-pro
Concern over the impact of misinformation has continued to grow, as high levels of belief in misinformation have threatened democratic legitimacy in the United States1 and global public health during the COVID-19 pandemic2. Considerable attention among scholars, media and policymakers alike has been paid to the role of social media platforms in the spread of, and belief in, misinformation3,4, with
The development and widespread availability of generative artificial intelligence (AI) tools, such as ChatGPT (https://openai.com/) or MidJourney (https://www.midjourney.com), has sparked a lively debate about numerous aspects of their integration into society1, as well as about the nature of creativity in humans and AI2. One of the key issues surrounding the implementation of AI technologies pert
Patients with treatment-resistant depression (TRD) experience a wide variety of debilitating symptoms, including persistent negative mood, anhedonia, psychomotor retardation and suicidal thoughts. While many patients with TRD who receive experimental subcallosal cingulate (SCC) deep brain stimulation (DBS) have responded to continuous stimulation with durable symptom relief4,5,6,7,8, the clinical
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