Adult Outcomes of Youth Irritability: A 20-Year Prospective Community-Based Study Argyris Stringaris, M.D., M.R.C.Psych., Patricia Cohen, Ph.D., Daniel S. Pine, M.D., and Ellen Leibenluft, M.D. OBJECTIVE: Irritability is a widely occurring DSM-IV symptom in youths. However, little is known about the relationship between irritability in early life and its outcomes in mid-adulthood. This study ex