The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable - Nature Medicine

To the Editor — The global demand for prophylactic and treatment options for COVID-19 has in turn created a demand for both randomized clinical trials, and the synthesis of those trials into meta-analyses by systematic review. This process has been fraught, and has demonstrated the inherent risks in current approaches and accepted standards of quantitative evidence synthesis when dealing with high

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"@EARL_COVID19_tw イベルメクチンが新型コロナウイルスに有効との結果を示したNiaeeらのRCTに疑義がかかり，生データ提出を求めたが執筆者が拒否．（Nat Med 2021, Sep22） ポジティブ結…" from https://twitter.com/i/web/status/1440956288293224454